Study on Cytogenetics of 5,488 Couples with Abnormal Pregnancy-Labor History

Objective To analyze the relationship between abnormal cytogenetics and abnormal pregnancy-labor history.Methods Peripheral blood sample from 5,488 couples with abnormal pregnancy-labor history was collected.Then the chromosomal karyotype was analyzed through the culture of peripheral blood lymphocyte and G-dominance band of the chromosomes.Results Totally we detected abnormal chromosome karyotype in 443 cases.The overall incidence of chromosomal abnormalities was 4.04%.Abnormal karyotype included numerical abnormalities for 25 cases,balanced-translocation for 182 cases,pericentromric inversions for 67 cases,polymorphic variation for 166 cases,and deletion for 3 cases.Conclusions Abnormal pregnancy-labor history is not only associated with chromosome aberration,but also with chromosome polymorphism.It is necessary for couples with abnormal pregnancy-labor history to take chromosome examination.It will be helpful to analyze the etiology and offer guidance for subsequent pregnancy and clinical therapy.