Application of serum total bile acid determination in infantile hepatitis syndrome

Objectives To determine the significance of serum total bile acid (TBA) in the diagnosis and treatment of infantile hepatitis syndrome. Methods Serum TBA and other liver function related items were determined with automatic enzymatic assay techniques in 67 with infantile hepatitis syndrome patients (age 26 days～7 months) and 100 normal infants (age 20 days～1 year). Results In the control group, the serum TAB level was 0～11.3 μmol/L. TBA level was abnormal in 89.5% patients and the values were 0.5～226.0 μmol/L ±s =(79 5±54.3) μmol/L]. The difference was significant between the two groups. The TBA levels were well related to those of ALP, DBIL and γ GT and TBA was better than others in sensitivity and specificity. . The difference was significant between the two groups. The TBA levels were well related to those of ALP, DBIL and γ GT and TBA was better than others in sensitivity and specificity. Conclusion Serum TBA level is important in evaluating the diagnosis, treatment, and prognosis of infantile hepatitis syndrome.