The Characteristics of the RANTES Gene Polymorphism in Chinese Hui and Han Population of Ningxia

Objective To investigate the distribution traits of RANTES gene polymorphisms in Ningxia Hui and Han population.Methods Polymerase Chain Reaction(PCR) and Restriction Fragment Length Polymorphism(RFLP) technique were used to type the SNPs of-403(G / A) and-28(C / G) of RANTES gene.Results In Ningxia Hui population,the genotype frequencies of-403G /A(GG,GA and AA) of RANTES gene were 37.5%,46.6% and 15.9% respectively.Allele frequencies(G and A) of-403G / A were 60.8% and 39.2%.The genotype frequencies of-28C / G(CC,CG and GG) were 71.0%,27.3% and 2.7% respectively.And allele frequencies(C and G) of-28C / G were 84.7% and 15.3%.In Ningxia Han population,the genotype frequencies of-403G / A(GG,GA and AA) of RANTES gene were 43.9%,43.9% and 12.1% respectively.Allele frequencies(G and A) of-403G / A were 65.9% and 34.1%.The genotype frequencies of-28C / G(CC,CG and GG) were 75.7%,22.0% and 2.3% respectively.Allele frequencies(C and G) of-28C / G were 86.7% and 13.3%.There were not statistically significant(P 0.05) between the two groups.Conclusion The polymorphisms of-403 G / A and-28 C / G in RANTES gene were no significant difference between Ningxia Hui and Han population.