Comparative analysis of efficacy of sequential therapy,quadruple therapy and standard triple therapy for the eradication of helicobacter pylori

Objective To compare the efficacy of sequential therapy,quadruple therapy and standard triple therapy for the eradication of helicobacter pylori(Hp).Methods A total of 105 Hp positive patients were selected and randomly divided into three groups.Group A received sequential therapy,group B received quadruple therapy and Group C received standard triple therapy.Endoscopy,rapid urease test and 14C breath test were done 4 weeks after review,and the improvement of chronic gastritis,ulcer healing and eradication of Hp circumstances were observed.Results Quadruple therapy and sequential therapy containing secretagogues showed good efficacy(Hp eradication rates,improvement of chronic gastritis and ulcer healing,and Hp infection recurrence rate) to Hp-positive chronic gastritis and peptic ulcer patients,while standard triple therapy was significantly worse than the other two kinds of programs.Three kinds of programs hair adverse reaction rate was lower,and was not serious.Conclusion Quadruple therapy and 10 d sequential therapy containing secretagogues are more effective than standard triple therapy in the eradication of Hp,chronic gastritis.It can promote ulcer healing and reduce the relapse rate,but it does not increase the incidence and severity of adverse reactions,which can be used as the preferred solution to Hp infection in patients with no previous treatment.