Study of Ge Pi Decoction on regulation of monocyte chemoattractant protein-1 level to reverse early diabetic nephropathy

Objective:To investigate the effect of Ge Pi decoction on regulation of monocyte chemoattractant protein-1(MCP-1)level to reverse early diabetic nephropathy(DN).Method: STZ diabetes model were induced by high lipoids and high glucose diet combined with intraperitoneal injection of small dose streptozotocin(STZ)(n = 41).STZ-induced diabetes model of Wistar male rats were divided into the control group(n = 14),the Traditional Chinese medicine(Ge Pi Decoction) treatment group(n = 13),and the western medicine(benazepril) treatment group(n = 14).After 8 weeks,detection of each group were carried out about weight,kidney weight index,blood glucose,urinary albumin microdosis,urinary albumin,blood and urine MCP-1,8-iso-prostaglandin F2a(8-iso-PGF2α)and tumor necrosis factor-α(TNF-α),and oservation were performed on the pathological change of the rats renal with light microscope.Result: Compared with those in the control group,the body weight and kidney weight index were decreased in the Ge Pi Decoction treatment(P 0.05).Microdosis urin-albumin,MCP-1,8-iso-PGF2α and TNF were decreased significantly(P 0.01).There was no significant difference between Ge Pi Decoction treatment group and benazepril treatment group(P 0.05).In addition,there were positive correlation between 8-iso-PGF2α,MCP-1,TNF-α and UAER in each group.Ge Pi Decoction can relieve kidney hypertrophy,mesangial matrix hyperplasia and sclerosis.Conclusion: There are autoimmunity inflammation and oxidative stress in diabetic nephropathy.Ge Pi Decoction can inhibit various inflammatory factors in diabetic nephropathy.