The clinical significance of heart type fatty acid-binding protein in diagnosis of acute myocardial infarction

Objective To study the diagnostic significance of heart type fatty acid-binding protein(H-FABP) in acute myocardial infarction(AMI).Methods H-FABP,cardiac troponin I(cTnI) and creatine kinase(CK)-MB mass were detected in 78 patients with AMI,52 patients with unstable angina(UA),65 patients with stable angina(SA) and 70 healthy controls by double antibody sandwich enzyme-linked immunosorbent assay.32 blood samples were collected within 2 h after AMI occurrence,and 46 blood samples were collected after AMI occurrence more than 2 h.Their H-FABP levels were detected and compared with cTnI.The diagnostic significance was analyzed.Results The levels of H-FABP,CK-MB mass and cTnI of AMI group [(78.12±23.78)μg/L,(9.48±2.68)μg/L and(10.12±3.45)ng/mL] were significantly higher than those of UA group [(18.67±7.45)μg/L,(0.56±0.11)μg/L and(0.21±0.12)ng/mL],SA group [(2.98±1.65)μg/L,(0.22±0.08)μg/L and(0.08±0.06)ng/mL]and control group [(2.32±1.12)μg/L,(0.20±0.09)μg/L and 0.022 ng/mL](P0.05).H-FABP,CK-MB mass and cTnI of UA group were significantly higher than those of SA group and control group(P0.05).The H-FABP,CK-MB mass and cTnI levels had no difference between SA group and control group(P0.05).The sensitivity,specificity,accuracy,positive predictive value and negative predictive value of H-FABP in AMI diagnosis were 84.89%,98.8%,85.89%,93.24% and 75.14%,which were higher than CK-MB mass(50.11%,89.12%,78.54%,80.12% and 50.78%) and cTnI(60.22%,93.23%,80.34%,86.45% and 60.56%) respectively.In the 32 cases′ blood collected within 2 h,the positive rate of H-FABP(65.63%) was higher than that of cTnI(18.75%)(P0.05).In the 46 cases′ blood collected after more than 2h,the positive rate of H-FABP(97.83%) had no statistical difference with that of cTnI(89.13%)(P0.05).Conclusions H-FABP has good sensitivity and specificity in the diagnosis of AMI.H-FABP is a clinically promising marker of AMI.