The significance of heart-type fatty acid-binding protein for early diagnosis of acute myocardial infarction

Objective To investigate the significance of heart-type fatty acid-binding protein(H-FABP) for the early diagnosis of acute myocardial infarction(AMI).Methods A total of 144 patients suffered chest pain as the main syndrome were enrolled in the study.The patients were AMI suspected(90 truth cases and 54 suspicion cases).By enzyme-linked immunosorbent assay(ELISA),serum samples were detected respectively within 3 h and after 6 h of chest pain onset.The H-FABP,cardiac troponin I(cTnI) and creatine kinase isozyme-MB(CK-MB) were detected,and the sensitivity,specificity and diagnostic accuracy in the early diagnosis of AMI were compared.Moreover,60 healthy subjects with similar age and sex were as the control group.Results The level of H-FABP [(56.13±19.17) ng/mL] in AMI group was obviously higher than those in the suspected group [(11.46±4.85) ng/mL] and the control group [(3.14±1.52) ng/mL] within 3 h(P0.01).Furthermore,its seropositive rate(91.11%),sensitivity(91.11%),specificity(98.33%),diagnostic accuracy(94.67%),positive predictive value(98.80%) and negative predictive value(88.24%) were obviously better than cTnI(13.33%,13.33%,96.67%,48.00%,85.71% and 43.48%) and CK-MB(21.11%,21.11%,95.00%,52.67%,86.36% and 48.80%)(P0.05,P0.01).The cTnI and CK-MB levels in AMI group were obviously higher than those in the suspected group and the control group after 6 h(P0.01).Conclusions Within 3 h of AMI onset,H-FABP shows good sensitivity,diagnositic accuracy and negative predictive value.H-FABP can be used in the early diagnosis of AMI.