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2010•Practical Journal of Cardiac Cerebral Pneumal and Vascular DiseaseRequires access

Distribution and Drug Resistance Analysis of Klebsiella Pneumoniae Producing Extended Spectrum Beta-lactamases

Zhao De-ju

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Abstract

Objective To investigate the distribution and durg resistance of Klebsiella pneumoniae producting extended spectrum beta-lactamases (ESBLs) in hospital.Methods ESBLs was detected by NCCLS phenotypic confirmatory test in K.pneumoniae which were isolated from 2009-01-01 to 2009-12-31 in the hospital.Antimicrobial susceptibility was tests by Kirby-Bauer method.The distribution and drug resistance of stanins producing ESBLs was analyzed.Results The detection rate of K.pneumoniae producing ESBLs was34.4%.The distribution of specimens mainly came from sputum and respiratory secretions.ESBLs producing strains to imipenem resistance rate was 0% to piperacillin/tazobactam.Conclusion ESBLs producing bacteria to commonly used antibiotics in vitro antibacterial activity was significantly higher than that of non-ESBLs producing bacteria,carbapenem antibiotic imipenem infection in the treatment of strains producing ESBLs ideal drug.

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Objective To investigate the distribution and durg resistance of Klebsiella pneumoniae producting extended spectrum beta-lactamases (ESBLs) in hospital.Methods ESBLs was detected by NCCLS phenotypic confirmatory test in K.pneumoniae which were isolated from 2009-01-01 to 2009-12-31 in the hospital.Antimicrobial susceptibility was tests by Kirby-Bauer method.The distribution and drug resistance of stanins producing ESBLs was analyzed.Results The detection rate of K.pneumoniae producing ESBLs was34.4%.The distribution of specimens mainly came from sputum and respiratory secretions.ESBLs producing strains to imipenem resistance rate was 0% to piperacillin/tazobactam.Conclusion ESBLs producing bacteria to commonly used antibiotics in vitro antibacterial activity was significantly higher than that of non-ESBLs producing bacteria,carbapenem antibiotic imipenem infection in the treatment of strains producing ESBLs ideal drug.

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Available abstract

Objective To investigate the distribution and durg resistance of Klebsiella pneumoniae producting extended spectrum beta-lactamases (ESBLs) in hospital.Methods ESBLs was detected by NCCLS phenotypic confirmatory test in K.pneumoniae which were isolated from 2009-01-01 to 2009-12-31 in the hospital.Antimicrobial susceptibility was tests by Kirby-Bauer method.The distribution and drug resistance of stanins producing ESBLs was analyzed.Results The detection rate of K.pneumoniae producing ESBLs was34.4%.The distribution of specimens mainly came from sputum and respiratory secretions.ESBLs producing strains to imipenem resistance rate was 0% to piperacillin/tazobactam.Conclusion ESBLs producing bacteria to commonly used antibiotics in vitro antibacterial activity was significantly higher than that of non-ESBLs producing bacteria,carbapenem antibiotic imipenem infection in the treatment of strains producing ESBLs ideal drug.

Key concepts: Klebsiella pneumoniae, Imipenem, Microbiology, Medicine, Piperacillin, Drug resistance, Tazobactam, Sputum

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