Analysis of drug resistance of Klebsiella pneumoniae

Objective To investigate the drug resistance of clinical isolates of Klebsiella pneumoniae in our hospital for providing clinical reference. Methods Antimicrobial susceptibility test is analyzed by K-B paper scraps spread method.The extended spectrum beta-lactamases(ESBLs) producing strains were detected by double disc test and confirmed test. Results The ESBLs positive rate of Klebsiella pneumoniae was 40.6%.The highest resistance of Klebsiella pneumoniae to TCC was 97.9% and the resistance to other 10 antibiotics was over 50% except amikacin and imipenem.The resistance to imipenem was 3.6%.There no significant statistical differences were observed in resistance of ESBLs producing strains and non-ESBLs producing strains to TCC and imipenem(P0.05).There were significant statistical differences were observed in resistance of ESBLs-producing strains and non-ESBLs producing strains to other 10 antibiotics(P0.01). Conclusion The Klebsiella pneumoniae which produced ESBLs strains is one of the main of opportunistic infection strains.Thus monitoring activities be carried out for preventing the prevalence of resistant Klebsiella pneumoniae strains.