Expression of VEGF in Breast Cancer Tissue and its Clinical Significance

Objective To investigate the expressions of vascular endothelial growth factor(VEGF) in serum and breast cancer tissues,and to explore their relationships with the occurrence,development and lymph node metastasis of the cancer.Methods VEGF expression in the breast cancer tissue of different histological types was determined by immunohistochemistry,and VEGF level in serum was detected by ELISA.Results The positive rate of VEGF expression was increased with the progress of the histological grade of the breast cancer.The positive rate of VEGF in the lymph node metastasis group was 92.86%(26/28),while that in the non lymph node metastasis group was 81.82%(18/22).The serum VEGF level in the lymph node metastasis group was significantly higher than that in the non lymph node metastasis group(P0.05).The serum VEGF level was not significantly different between the normal control group and the benign breast cancer group(P0.05),while that in the malignant breast cancer group was significantly higher than those in the other two groups(P0.01).Conclusions VEGF is highly expressed in breast cancer.It may correlate with the malignancy and node metastasis of the cancer.Detection of VEGF is of important significance in predicting node metastasis of breast cancer.