Large Y Chromosome Cytogenetic Studies and Their Clinical Effect Analysis

Objective To explore the relationship between large Y chromosome and adverse pregnancy as well as clinical significance.Methods:Preparation of peripheral blood lymphocyte culture of conventional chromosome specimens,G-banding karyotype analysis of 716 cases were Detected.Results:Detected 124 cases of abnormal karyotype,Male 56 cases of abnormal karyotype,Large Y chromosome carriers of 38 cases,Accounting for abnormal male karyotype of 67.86%,Large Y chromosome carriers Could lead to his spouse happened habitual abortion,low infant birth intellectual,long-term infertility,history has stillbirth,children have abnormal reproductive history and neonatal deaths and abortion and so on.Conclude:Large Y chromosome was related with adverse pregnancy,and have the clinical significance.