Anti-fatigue Effects of Polysaccharides Derived from Dendrobium nobile Lindl. in Mice

Purpose: To investigate the anti-fatigue effects of polysaccharides derived from Dendrobium nobile Lindl(DNP) in mice.Methods: The anti-fatigue effect of polysaccharides was evaluated based on the forced swimming performance and the changes of biochemical parameters in ICR mice.Mice were orally administrated with DNP at a dose of 500 mg/(kg.d) day for 4 successive weeks to create a treatment group and those given distilled water every day were assigned to a control group.After the end of the 4-week administration period,all mice were subjected to weight-loaded forced swim test and then measured for swimming time and biochemical indicators such as blood triglyceride,blood sugar,blood ammonia and glycogen.Results: Compared with distilled water,DNP especially alkaline-soluble DNP could significantly lengthen the swimming time of mice,increase blood triglyceride and glucose levels,and reduce blood lactic acid and ammonia levels,and post-swimming hepatic and muscle glycogen consumption in mice.Conclusion: DNP can exert anti-fatigue effects in mice by increasing fat utilization and delaying the accumulation of plasma lactic acid and ammonia.