Relationship between the Level of Cholinesterase and the Patients Condition and the Prognosis of Sepsis

Objective To explore the relationship between the level of cholinesterase and the patients condition and the prognosis in the patients with sepsis.Methods From June 2007to June 2009,89patients with sepsis were selected as the sepsis group,whose cholinesterase level was assayed and evaluated by APACHEⅡscore.Another 82 healthy people were as the control whose cholinesterase level was assayed and compared with that in the sepsis group. The patients in the sepsis group were subdivided into survival and death group;the level of cholinesterase and the result of APACHEⅡscore were compared between the two groups.Results The level of cholinesterase in sepsis group was significantly lower than that in the control group before treatment,and the difference was significant(P 0.01);the APACHEⅡscore negatively correlated with the serum cholinesterase in sepsis group.The APACHEⅡ score in the death group was significantly higher than that in the survival group,but the level of cholinesterase was obviously lower in the death group than that in the survival group(P0.01).Conclusion The serumal cholinesterase negatively correlates with the APACHE Ⅱ score,which could obviously reflect the patients condition and the prognosis of sepsis.