Value of s100β protein detection in cerebrospinal fluid and serum in diagnosis of Creutzfeldt-Jakob disease

Objective To explore the significance of detecting s100β protein in cerebrospinal fluid (CSF) and serum in diagnosis of Creutzfeldt-Jakob disease (CJD). Methods The content of s100β protein in CSF and serum of 13 patients with CJD (CJD group), 6 patients with Alzheimer disease (AD group) and 18 patients with central nervous system diseases without dementia (CNS group) were determined by ELISA. Results The content of s100β protein in CSF and serum of CJD group were significantly higher than those of AD group and CNS group (both P0.01). Conclusions The content of s100β protein in CSF and serum could be one of diagnostic indexes of CJD.