Effects of Metformin on Clomiphene-Induced Ovulation in the Polycystic Ovary Syndrome

Objective:To observe the effects of metformin plus clomiphene in the treatment of patients with polycystic ovary syndrome(PCOS).Methods:Forty PCOS patients with infertility were randomly divided into two groups,patients in group A (n=20) were given metformin,1 500 mg daily for one cycle from 1～3 day in menstral cycle,after one cycle,plus clomiphene citrate 100mg/day×5 for induction of ovulation,patients in group B were induced ovulation with CC alone for 1 cycle. The levels of serum FSH,LH,T glucose and insulin were measured in all patients.Results:In group A,the levels of serum LH.T and Fins were significantly decreased when compared with those of pre-treatment Levels (P0.05). 9 of the 20 patients (45 percent) became pregrancy. In group B,3 of the 20 patiens (15 percent) became pregnancy.The pregnant rates between two groups showed significantly differences (45% vs 15%,P0.05).Conclusions:Metformin therapy not only decreases high LH and insulin resistance but also improves pregnant rates combined with clomiphene to the patients with PCOS.