Association Between A-LAP Gene Polymorphism and Essential Hypertension

Objective To study the relationship between A-LAP gene A828G polymorphism and essential hypertension.Method The A-LAP gene A828G polymorphism was detected in 135 patients with essential hypertension and 135 controls by PCR-RFLP.Results The frequencies of AA,GG and AG genotype were 61.5%,1.5%,and 37.0% in the control group and 48.1%,5.9%,and 45.9% in the hypertensive group respectively,significant difference of the allele distributions frequencies in these 2 groups was evident(χ2=7.075,df=2,P=0.029).A and G allele distribution frequencies in these 2 groups were 80.0% and 20.0% in the control group,71.1% and 28.9% in the hypertensive group;again significant difference of A and G distributions frequencies in these 2 groups was evident(χ2=5.775,df=1,P=0.016).Conclusions There is a relationship between the A-LAP gene A828G polymorphism and hypertension.G allele may be a risk factor of hypertension.