Study on the relation between the CYP11B2 gene polymorphisms and essential hypertension

Objective To explore the relation between the polymorphism-344T/C of aldosterone synthase gene(CYP11B2) and essential hypertension.Methods Association analysis was employed and the single nucleotide polymorphisms of genomic DNA from 100 patients with essential hypertension and 100 normal Han subjects in Hunan randomly selected according to a standard were genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) analysis.Results There was no significant difference of gene frequency(TT,TC,and CC) between the hypertensive and the control groups(χ2=0.34,P0.05),so did the distributions of T and C alleles in both groups(χ2=0.28,P0.05).The frequency of T allele was higher than that of C allele in both groups(hypertension: 67.67% vs 32.33%,P0.05;controls: 69.67% vs 30.33%,P0.05).Conclusions Polygene associated assay shows that the polymorphism of CYP11B2-344C has not obvious connection with essential hypertension in male case,while the frequency of T allele of CYP11B2-344C in both groups was higher than that of C allele,which has obvious connection with essential hypertension.