Comparison Study on the In Vitro Antimicrobial Activity of Five Common Used Broad spectrum Beta lactams

Purpose To evaluate the antimicrobial activity of five broad spectrum beta lactams in common use. Methods Employing E test method to determine the minimum inhibiting concentration(MIC)of antibiotics against 100 strains bacteria. Results The rank order of susceptibility of the five antimicrobial agents was imipenem(94%),cefoperazone/sulbactam (76%),ceftazidime (68%),ceftriaxone (65%),piperacillin (38%). Conclusions Imipenem is the most active antimicrobial agent that almost against all bacteria;the antimicrobial activity of ceftazidime against aram negative rods is more active than that against gram positive cocci,especially,predominantly against Pseudomonas aeruginosa.