Effect on the early application of intravenous metoprolol to patients with acute myocardial infarction.

Objective:To access the clinical effect of early intravenous metoprolol therapy in patients with acute myocardial infarction(AMI).Methods:87 patients after AMI were randomly divided into study group and control group.The control group was treated with combined therapy of rt-pA,LMWA,aspirin,ACEI,Nitroglycerin.The study group received 5mg metoprolo i.v.on the base of normal treatment,all together three times in every 5 minutes with the total of 15 mg,then the study group began oral application of metoprolo 25~50 mg,q12h.The heart rates,blood pressure,the persistent time of ST-segment elevating,heart failure syndrome,malignant ventricular arrhythmia and sudden death was observed.Results:The heart rate decreased obviously after intravenous metoprolol was injected,from(102.2±11.5)bpm to(86.8±11.1)bpm(P0.05);Intravenous metoprolol can treat and prevent arrhythmias effectively(P0.05);It can decrease the incidence of malignant ventricular arrhythmia and sudden death(P0.05).Conclusions:Intravenous metoprolol is safe and efficacious in the treatment of the patients with acute myocardial infarction.