2006•Qilu Pharmaceutical AffairsRequires access

Determination of baicalin in Kuiyangsan Capsules by HPLC

Wenqi Liu

Abstract

OBJECTIVE To establish a method for the determination of baicalin in Kuiyangsan Capsules.METHODS HPLC method was developed for the determination of baicalin in Kuiyangsan Capsules on Kromasil C_ 18(250mm×4.6mm,5μm),using methanol-water-H_3PO_4(47∶53∶0.2,v∶v)as a mobile phase(1.0ml·min-1)and detection wavelength was 280nm.RESULTS The calibration curve of baicalin was linear in the range of 0.3028～1.514μg(r=0.9995),and the average recovery was 97.65%(RSD=1.17%,n=6).CONCLUSION The method was convenient and accurate.It can be used for the quality control of Kuiyangsan Capsules.

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Key concepts: Baicalin, Calibration curve, Chromatography, High-performance liquid chromatography, Chemistry, Methanol, Linear range, Detection limit