Correlation of N-Terminal-pro-B-type natriuretic peptide with heart function and prognosis of heart failure patients

Aim To investigate correlation between N-Terminal-pro-B-type natriuretic peptide (NT-proBNP) and the the heart function of heart failure patients.Methods The levels of serum or plasma NT-proBNP in 106 heart failure patients classified by NYHA were measured by electrochemiluminescent immunoassay,the left ventricular structure and LVEF were examined by echocardio-graphy,last correlation was analysed with nonparametric test.Results The level of NT-proBNP showed negative correlation with the value of LVEF(r=-0.736,P0.05).along with the increase of the grade of NYHA,the content of NT-proBNP went up.the level of NT-proBNP in patients with valid treatment show distinct decrease through dynamicly monitoring,but the level of NT-proBNP in patients died of heart failure were higher than before treatment.Conclutions The level of NT-proBNP can reflect the state of the heart function and it is of important significance in diagnosis,treatment,monitorit and prognosis of heart failure failure.