The serum aspartate transaminase, γ-glutamyltransferase and bilirubin level were associated with liver stiffness

Objective To study the correlation between liver functions and liver stiffness in patients with chronic hepatitis B (CHB). Methods Thirty-five patients with CHB were enrolled. The liver stiffness values (measured by Fibroscan), serum ALT, AST, GGT, ALB, GLO and TBIL were detected twice during an interval of 1-33 weeks. The relationship between values of liver function or age and liver stiffness values, between the changes of twice liver function values or the times of detection intervals and the changes of liver stiffness were investigated. Multivariate regression analysis was carried out, with the liver stiffness changes as the dependent variable, the changes of ALT, AST, GGT, ALB, GLO, TBIL, DBIL, age and the times of detection interval as independent variables. Result The GGT, ALB, TBIL and DBIL levels were correlated with liver stiffness; Age, and the changes of AST, GGT, GLO, TBIL and DBIL were correlated with the changes of liver stiffness (r=0.380, 0.503, 0.536, 0.369, 0.341, 0.497; P0.05). The times of detection interval and the changes of liver stiffness had shown no significant correlation (P 0.05). Multivariate regression analysis showed: liver stiffness value changes=0.4982 × GLO changes + 0.4621 × DBIL changes (F=15.108, P0.001). Conclusion The degree of inflammation affected the liver stiffness values. However, it is difficult to accurately assess the degree of liver fibrosis by Fibroscan test by corrected AST levels.