Cytogenetic study of Amenorrhea cases in Changzhou area

Objective:To investigate the distribution and the characteristics of karyotypes in amenorrhea patients in Changzhou city.Methods:Cytogenetic karyotyping analysis was carried out routinely.Results:During 1996 to 2009,201 cases of amenorrhea were per-formed karyotyping analysis.59 cases were found abnormal,the rate was 29.4%.Among them,26 cases were the X-chromosome number abnormalities (44.1%);16 cases were simple X chromosome structural abnormalities (27.1%);12 cases were superfluous Y chromosome (20.3%);4 cases were combined X chromosome structural abnormalities(6.8%);just 1 case was autosomal exception(1.7%).Conclusion:Amenorrhea,in particular,primary amenorrhea is closely related with chromosomal abnormalities.Cytogenetic examination had advantages of clarifying the causes and effective treatment.