2009•Chinese Journal of Veterinary DrugRequires access

Mechanism and Application of RNA Interference in Aquatic Organism

Guo Yi-hui

Abstract

The mechanism,application of RNAi and preparation of siRNA(small interfering RNA) were reviewed in this paper.RNA interference(RNAi) is a kind of post-transcriptional gene silencing(PTGS) phenomenon,which can specifically degrade its homologous mRNA in cell by external or internal double-stranded RNA(dsRNA),result in the corresponding gene silencing and obtain the aim of stopping the gene expression.Because of its advantages such as being efficient and specific,RNAi provided methods for breaking intracellular gene expression research and will be used widely in the future.

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Available abstract

Key concepts: RNA interference, RNA silencing, Gene silencing, DNA-directed RNA interference, RNA, Small interfering RNA, Gene expression, Gene