Clinical research of treament with PGE_(1) combining traditional Chinese medicine on diabetic nephropathy

To investigate the co-effect of prostaglandin E1(PGE1) and traditional Chinese Medicine on renal founction and urine albumin of patients with diabetic nephropathy (DN). 90 patients aged 33 to 47 years old with DN (male: 47 cases, female: 43cases) were divided into treatment group (60 cases) and control group (30 cases) according to urine albumin and renal founction. Tow groups were divided into earlier period nephropathy group and renal insufficiency group.The treatment group was divided into two groups: PGE1 group and PGE1 combining traditional Chinese medicine group. The latter received daily PGE1 100 μg and ledocaine 100 mg solved in 250 mL NS intravenously and daily one traditional Chinese medicine for 21 days. The control group did not adopt this method.There was not different between two groups in the other treated methods including lower blood pressure, lipid and blood sugar. Compared with the control group, the urine albumin level decreased significantly in PGE1 combining traditional Chinese medicine group and the urine albumin level decreased from (236±79) mg/24 h to (96±61) mg/24 h in earlier period nephropathy group, from (2532±770) mg/24 h to (1796±660) mg/24 h in renal insufficiency group after treatment. The urine albumin level had not changed from treatment termination to following-up 3 month in treatment group. [Conclusion] The urine albumin level can be decreased by the combination of PGE1 and traditional Chinese medicine and is not increasing in following-up 3 month in different period patients with DN.