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β-aescine Sodium for Brain Edema Caused by Metastatic Brain Tumor: Observation of Curative Efficacy

Yu Zhang

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Abstract

OBJECTIVE: To observe the efficacy of β-aescine sodium in the treatment of brain edema caused by metastatic brain tumor.METHODS: A total of 58 patients,who have been diagnosed pathologically as having non-intracranial tumor and verified as having brain metastasis by CT and/ or MRI were randomized to mannitol group(at a dose of 1g· kg-1· d-1),β-aescine sodium group(20mg· d-1),or combined group(mannitol plus β-aescine sodium group) for 7 days or 7～ 10d(for the severe cases).RESULTS: The effective rate in mannitol group(80%) resembled that in β-aescine sodium group(75%),but both were significantly lower than in the combined group(91%)(P0.05).CONCLUSION: β-aescine sodium is effective for brain edema induced by metastatic brain tumor,and which had a better efficacy when used concomitantly with mannitol.

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What this paper is about

OBJECTIVE: To observe the efficacy of β-aescine sodium in the treatment of brain edema caused by metastatic brain tumor.METHODS: A total of 58 patients,who have been diagnosed pathologically as having non-intracranial tumor and verified as having brain metastasis by CT and/ or MRI were randomized to mannitol group(at a dose of 1g· kg-1· d-1),β-aescine sodium group(20mg· d-1),or combined group(mannitol plus β-aescine sodium group) for 7 days or 7～ 10d(for the severe cases).RESULTS: The effective rate in mannitol group(80%) resembled that in β-aescine sodium group(75%),but both were significantly lower than in the combined group(91%)(P0.05).CONCLUSION: β-aescine sodium is effective for brain edema induced by metastatic brain tumor,and which had a better efficacy when used concomitantly with mannitol.

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Available abstract

OBJECTIVE: To observe the efficacy of β-aescine sodium in the treatment of brain edema caused by metastatic brain tumor.METHODS: A total of 58 patients,who have been diagnosed pathologically as having non-intracranial tumor and verified as having brain metastasis by CT and/ or MRI were randomized to mannitol group(at a dose of 1g· kg-1· d-1),β-aescine sodium group(20mg· d-1),or combined group(mannitol plus β-aescine sodium group) for 7 days or 7～ 10d(for the severe cases).RESULTS: The effective rate in mannitol group(80%) resembled that in β-aescine sodium group(75%),but both were significantly lower than in the combined group(91%)(P0.05).CONCLUSION: β-aescine sodium is effective for brain edema induced by metastatic brain tumor,and which had a better efficacy when used concomitantly with mannitol.

Key concepts: Mannitol, Brain edema, Medicine, Edema, Sodium, Brain metastasis, Brain tumor, Internal medicine

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β-aescine Sodium for Brain Edema Caused by Metastatic Brain Tumor: Observation of Curative Efficacy — Research Paper | ScholarLens