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2008•Journal of Chengdu UniversityRequires access

Simultaneous Determination of Aspirin and Salicylic Acid Impurity in Aspirin Tablets by HPLC

Gou Xiao-jun

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Abstract

To establish a HPLC method for the determination of aspirin and salicylic acid in aspirin tablets,acetonitrile-methanol-formic acid(40∶59∶1) was used as extracted solvent.The mobile phase was composed of acetonitrile-methanol-0.01 mol/L potassium dihydrogen phosphate(adjusting pH to 3.3～3.4 with phosphoric acid).A linearity with a good correlation coefficient was yielded from 0.183 to 0.427 mg/mL for aspirin(r=0.9997).The average recovery was 99.81% and RSD was 0.24%.A linearity with a good correlation coefficient was yielded from 1 to 12 μg/mL for salicylic acid(r=0.9999).The average recovery was 101.09% and RSD was 0.77%.This method is simple,sensitive,accurate and precise,and can be used for the quality control of the preparation.

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What this paper is about

To establish a HPLC method for the determination of aspirin and salicylic acid in aspirin tablets,acetonitrile-methanol-formic acid(40∶59∶1) was used as extracted solvent.The mobile phase was composed of acetonitrile-methanol-0.01 mol/L potassium dihydrogen phosphate(adjusting pH to 3.3～3.4 with phosphoric acid).A linearity with a good correlation coefficient was yielded from 0.183 to 0.427 mg/mL for aspirin(r=0.9997).The average recovery was 99.81% and RSD was 0.24%.A linearity with a good correlation coefficient was yielded from 1 to 12 μg/mL for salicylic acid(r=0.9999).The average recovery was 101.09% and RSD was 0.77%.This method is simple,sensitive,accurate and precise,and can be used for the quality control of the preparation.

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Available abstract

To establish a HPLC method for the determination of aspirin and salicylic acid in aspirin tablets,acetonitrile-methanol-formic acid(40∶59∶1) was used as extracted solvent.The mobile phase was composed of acetonitrile-methanol-0.01 mol/L potassium dihydrogen phosphate(adjusting pH to 3.3～3.4 with phosphoric acid).A linearity with a good correlation coefficient was yielded from 0.183 to 0.427 mg/mL for aspirin(r=0.9997).The average recovery was 99.81% and RSD was 0.24%.A linearity with a good correlation coefficient was yielded from 1 to 12 μg/mL for salicylic acid(r=0.9999).The average recovery was 101.09% and RSD was 0.77%.This method is simple,sensitive,accurate and precise,and can be used for the quality control of the preparation.

Key concepts: Salicylic acid, Phosphoric acid, Chemistry, Chromatography, Formic acid, Aspirin, Correlation coefficient, High-performance liquid chromatography

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