2007•Anhui Medical and Pharmaceutical JournalRequires access

Determination of paeoniflorin in danggui tiaojing granule by HPLC

Zhen Wang

Abstract

Aim To establish an HPLC method for the determination of paeoniflorin in danggui tiaojing granule.Methods The HPLC system consists of Kromasil C_ 18 column(200 mm× 4.6 mm,id 5 μm)acetonitrile-water(20∶80)mixture as mobile phase,with flow rate as 0.8 ml·min~ -1 and detection wavelength at 230 nm,and column temperature at 25℃.Results When paeoniflorin concentration is in the range of 8.4～210.0 mg·L~ -1 paeoniflorin has good linear relationship with peak area(r=0.999 8).The mean recovery was 97.12%,RSD=2.06%(n=5).Conclusion The method is sensitive and accurate. The reproducibility is good.The method could be used as quality control index for danggui tiaojing granule.

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Key concepts: Paeoniflorin, Chromatography, Granule (geology), High-performance liquid chromatography, Chemistry, Linear relationship, Linear range, Materials science