Clinical and Pathological Features of Gastrointestinal Stromal Tumor(GIST):a 39 Cases Report

Objective To explore the criteria of pathologic diagnosis for gastrointestinal stromal tumors(GIST)and the reference parameters for malignancy,and to evaluate the clinical prognosis.Methods The expression levels of CD117,CD34,SMA and S-100 were detected by immunohistochemical method and their morphologic characteristics were analyzed by Light microscopy.Results The immunohistochemical results showed that CD117 were diffusely strongly expressed in all of GIST;CD34 also diffusely strongly in most of GIST;SMA and S-100 incidentally in some focus.Their positive rates were 100%,81%,20% and 16% respectively.5 benign cases,10 potential malignancy cases and 24 malignant cases were finally diagnosed.Conclusion The pathologic diagnosis of GIST should be made based on the immunohistochemical staining results.CD117 was a sensitive and specific marker for diagnosing GIST.The prognosis was closely related to the degree of pathologic malignancy.