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Experimental Syndrome of Insulin Resistance Rat Model

Jian Wang

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Abstract

Objective:To establish experimental rat model with syndrome of insulin resistance.Methods:Adult male SD rats were divided into two groups and maintained for 8 wk on high-fat-sugar-salt diet and normal diet respectively.Both groups' water drinding amount,body weight,mean arterial BP,glucose tolerance,plasma TG,TC,and HDL-c,glucose and insulin levels,and insulin sensitivity index (ISI) were measured.Results:Compared with normal feeding,high-fat-sugar-salt feeding significantly increased water drinking amount (by 47%, P 0 01),body weight (by 11%, P 0 01),mean arterial BP (by 20%, P 0 01),the levels of plasma TG,TC,insulin (by 49%,57% and 69% respectively,all P 0 01) and glucose (by12%, P 0 05),and remarkably lowered the plasma HDL-c level (by30%, P 0 05) and the ISI ( P 0 01),and induced significant glucose intolerance.Conclusion:Rats fed diet high in fat,sugar and salt can develop to be animal models of syndrome of insulin resistance.

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What this paper is about

Objective:To establish experimental rat model with syndrome of insulin resistance.Methods:Adult male SD rats were divided into two groups and maintained for 8 wk on high-fat-sugar-salt diet and normal diet respectively.Both groups' water drinding amount,body weight,mean arterial BP,glucose tolerance,plasma TG,TC,and HDL-c,glucose and insulin levels,and insulin sensitivity index (ISI) were measured.Results:Compared with normal feeding,high-fat-sugar-salt feeding significantly increased water drinking amount (by 47%, P 0 01),body weight (by 11%, P 0 01),mean arterial BP (by 20%, P 0 01),the levels of plasma TG,TC,insulin (by 49%,57% and 69% respectively,all P 0 01) and glucose (by12%, P 0 05),and remarkably lowered the plasma HDL-c level (by30%, P 0 05) and the ISI ( P 0 01),and induced significant glucose intolerance.Conclusion:Rats fed diet high in fat,sugar and salt can develop to be animal models of syndrome of insulin resistance.

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Available abstract

Objective:To establish experimental rat model with syndrome of insulin resistance.Methods:Adult male SD rats were divided into two groups and maintained for 8 wk on high-fat-sugar-salt diet and normal diet respectively.Both groups' water drinding amount,body weight,mean arterial BP,glucose tolerance,plasma TG,TC,and HDL-c,glucose and insulin levels,and insulin sensitivity index (ISI) were measured.Results:Compared with normal feeding,high-fat-sugar-salt feeding significantly increased water drinking amount (by 47%, P 0 01),body weight (by 11%, P 0 01),mean arterial BP (by 20%, P 0 01),the levels of plasma TG,TC,insulin (by 49%,57% and 69% respectively,all P 0 01) and glucose (by12%, P 0 05),and remarkably lowered the plasma HDL-c level (by30%, P 0 05) and the ISI ( P 0 01),and induced significant glucose intolerance.Conclusion:Rats fed diet high in fat,sugar and salt can develop to be animal models of syndrome of insulin resistance.

Key concepts: Insulin resistance, Internal medicine, Medicine, Endocrinology, Insulin, Sugar, Blood sugar, Insulin sensitivity

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