Multisection dynamic CT perfusion for normal and tumorous pancreas

Objective To measure and assess CT perfusion for normal and cancerous pancreas by using multisection dynamic CT with tumor perfusion software package Methods The multisection dynamic CT perfusion series was performed for pancreatic perfusion with cine mode (1 s per rotation) on a multisection CT scanner (Lightspeed Ultra, GE, Waukesha, WI, USA), 4×5 mm collimation, 120 kV, 60 mA Contrast injection was done by using 50 ml nonionic contrast agent (300 mgI/ml), at a flow rate of 3 5 ml/s with a power injector, and 5 seconds delay, and data acquisition lasted for 45 seconds The mean BF, BV, MTT, and PS were measured and statistically analyzed in patients with normal pancreas ( n =37), pancreatic carcinoma ( n =37), and none-functioning islet cell tumor ( n =3) proven by clinic and pathology, respectively, on a Sun Ultra AW4 0 workstation using Perfusion 2 software package (GE) with deconvolution method Results The mean BF, BV, MTT, and PS in normal pancreas tissue were (3 386 2± 1 596 1)ml·min -1 ·kg -1 , (267 3±130 2)ml·kg -1 , 6 59±2 59 s, (288 2±203 9)ml·min -1 ·kg -1 , respectively The mean BF, BV, MTT, and PS in pancreatic carcinoma were (2 323 1± 1 841 2) m l·min -1 ·kg -1 , (189 7±160 6)ml·kg -1 , 7 93±3 92 s, (457 2±261 6)ml·min -1 ·kg -1 , respectively The mean BF, BV, and PS between pancreatic carcinoma and normal pancreas were statistically significant ( P =0 01,0 025, and 0 003) However, the mean MTT between pancreatic carcinoma and normal pancreas was not statistically significant ( P =0 087) Conclusion The pancreatic perfusion with multisection CT can be readily obtained The mean BF, BV, and PS between pancreatic carcinoma and normal pancreas were statistically significant