Study on the levels of plasma B-type natriuretic peptide and its significance among different clinical phenotypes of coronary heart disease

Objective To explore the relationship between plasma level of B-type natriuretic peptide (BNP) and clinical phenotypes of coronary heart disease (CHD) and the correlation between BNP and troponin T(TnT). Methods 90 patients with CHD were enrolled in this study and 28 persons without CHD were selected the as control.Clinical phenotypes of CHD included acute myocardial infarction (AMI),unstable angina pectoris (UAP) and stable angina pectoris (SAP). Plasma levels of BNP were detected at 16 hours after the appearance of symptoms in AMI or on admission in other groups and its clinical significances were analyzed.Correlation between BNP and TnT which was detected at the same time with BNP was also analyzed in AMI group.Results Plasma level of BNP were 566.23±129.53 pg/mL, 172.53±61.77 pg/mL, 40.06±24.33 pg/mL and 35.71±24.00 pg/mL in the patients with AMI,UAP,SAP and control respectively.The level of BNP was significantly higher in AMI than that in other three groups (P0.001,P0.001,P0.001);the level of BNP was significantly higher in UAP than that in SAP or control (P0.001,P0.001); there were no significant difference in BNP level between SAP and control (P0.05).BNP level were highly correlated with TnT in AMI (r=0.937,P0.001). Conclusion Plasma level of BNP are associated with clinical phenotypes of coronary heart disease and it may reflect degree of myocardial necrosis. [