Analysis on related factors of intracranial infection in patients after craniotomy

Objective To explore the risk factors of intracranial infection(ICI) in patients after craniotomy for providing a reference for its prevention and control. Methods The clinical data of 30 patients with postoperative intracranial infection were retrospectively analyzed and compared with 50 control patients without intracranial infection after craniotomy randomly chosen from 1 200 patients performing neurosurgery in our hospital from January 2006 to December 2009.The possible risk factors associated with ICI were firstly analyzed with single factor analysis,and then analyzed with multiple Logistic regression method. Results Univariate regression analysis showed that the surgical approach way,operation duration,cerebrospinal fluid leakage,ventricle external drainage were the risk factors for postoperative infection in patients after craniotomy(P0.05).The Logistic regression analysis found that ventricle external drainage(OR=8.096,P=0.006),cerebrospinal fluid leakage(OR=4.785,P=0.009),operation time(OR=2.798,P=0.021) and posterior fossa approach(OR=7.535,P=0.020)were risk factors for post-craniotomy intracranial infection. Conclusion Post-craniotomy intracranial infection in patients can be related with a single factor or multiple factors.But the ventricle external drainage,the cerebrospinal fluid leakage,the operation time and the posterior fossa approach are the high risk factors for postoperative intracranial infection.