Logistic Regression for Risk Factors Related to Intracranial Infection after Craniotomy

Objective To provide the basis for preventing and controlling intracranial infection after the craniotomy.Methods All the articles relevant to the intracranial infection after the craniotomy which were published at home from 1994 to 2004 were looked up and the risk factors related to the intracranial infection after the craniotomy were analysed by logistic regression.Results Forty-six articles were selected for meta-analysis.The data related to the constituent ratio of the risk factors of the intracranial infection after the craniotomy were extracted from 18 articles.Seven kinds of the risk factors related the intracranial infection after the craniotomy which were comparable with each other were extracted from 12 articles.The highest constituent ratio of the intracranial infection after the craniotomy was the operation that lasted more than four hours(54.81%).The others risk factors were cerebrospinal fluid drainage,posterior fossa operation,open craniocerebral injury,emergency operation and cerebrospinal fluid leakage in order of the constituent ratio.The cerebrospinal fluid leakage,open craniocerebral injury and posterior fossa operation were the risk factors closely related to the intracranial infection after the craniotomy(P0.05,OR1).ORs of cerebrospinal fluid leakage,open craniocerebral injury and posterior fossa operation were 11.587,3.024 and 2.737 respectively.Conclusions The most main risk factors of the intracranial infection after the craniotomy are cerebrospinal fluid leakage,open craniocerebral injury and posterior fossa operation.