Relationship between helicobacter pylori infection and chronic liver diseases

Objective:To study the relationship of helicobacter pylori(HP)infection between hepatic encephalopathy,upper gastrointestinal hemorrhage and hepatogenic ulcer(HU)in patients with chronic liver ailment.Methods:In 406 patients with chronic liver ailment,HBV-M and HCV was detected by ELISA;HBV-DNA and HCV-RNA were detected by PCR,and HP-cagA was detected by gold standard method.14C urea breath test was detected by HTY1001 HP in which 14C urea breath test ≥0.1dpm/mol Co2 was assessed HP active infection.Blood ammonia value was detected by colorimetric technique.Histological smears of HP was carried ou by taking 2 blocks mucous membrane of gastric antrum and stomach body.Hyperammonemia patients in 117 HP infection of the liver were divided into treatment group(64 cases)and control group(53 cases).Treatment group was given bismuth potassium citrate,clarithromycin and tinidazole,and control group was given lactulose in which hepatic tissue was performed Hp DNA amplification analysis by PCR.Results:The increased rate of Hp infection was significantly higher(47.2%)than that in control group(24.7%,P0.01).Incidence rate of hepatic encephalopathy in Hp positive group was 36.4%(4/11 case)and in control group was 60.0%(6/10 caes).Incidence rate of hepatic encephalopathy in contron group was higher than that in treatment group in which there was significant difference(P0.05)in two groups.Blood ammonia value was obviously lower in treatment group than control group after Hp eradication therapy.The rate of hemorrhage of upper digestive tract in HP postive grop was significantly higher(40.2%,47/117 case)than that in HP negative group(13.7%,18/131 case)in which there was significant difference(P 0.05)in two groups.In patients with HU,the incidence of HP was 60.5%(26/43 case)in HP positive rate group and non HU was 53.8%(35/65 case).The rate of Hp infection was 60.9%(39/64 case)in liver ulcersin group which was high than that of non-liver ulcersin group.16S rRNA gene of HP was amplified in hepatic tissue of a case.Conclusion:The rate of HP infection in patients with chronic liver ailment was significantly higher.HP infection is concerned with hepatic encephalopathy,upper gastrointestinal hemorrhage,HU and hepatic fibrosis in patients with chronic liver ailment.Eradication of Hp infection may play an improtant role on reducing and preventing beforehand hepatic encephalopathy,upper gastrointestinal hemorrhage,HU and Hepatic fibrosis in patients with chronic liver ailment.