Hepatic arterial perfusion thermochemotherpy and embolism for hepatic metastasis tumor

Objective:To evaluate the therapeutic effects of thermochemotherpy by intervention embolism for hepatic metastasis tumor.Methods: Sixty three cases with hepatic metastasis tumor were randomly divided into two groups,one with 30 cases and the other with 33 cases administered with thermochemotherpy and conventional chemotherapy respectively.The sodium chloride solution of 5-FU,Mitomycin and diamminedichloro platinum were given through selected hepatic artery to the two groups at 65℃ and normal temperature respectively.And then the feeding artery of carcinoma was embolismed with Lipiodol.All the cases were administered at least three times at intervals of one month.CEA and liver CT were performed every month to observe the level of CEA and the size,number and the lipiodol deposition of tumor.The survival rates were analyzed every month.Results: The 6-,12-,18-,and 24-month survival rate of thermochemotherpy group was 100%,93%,73% and 60% respectively which was different from the other group significantly(P0.01).The size and the number of tumor was smaller and less in thermochemotherpy group than that of conventional chemotherapy group(P0.01).While the Lipiodol deposition,body temperature,hepatic function and complication in two groups were similar(P0.05).Conclusion: Intervention thermochemotherpy embolism for liver metastasis tumor could increase the therapeutic effect and prolong the survival term of patients.