Effect of Apolipoprotein A5 in Lipids Metabolism and Coronary Heart Disease

Aim To discuss the relation among apolipoprotein A5(ApoA5) and lipid,coronary heart disease(CHD),try to find out the mechanism about ApoA5 regulating lipid levels and its function in coronary heart disease.MethodsThe level of serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDLC),low density lipoprotein cholesterol(LDLC),apolipoprotein A1(ApoA1),apolipoprotein B100(ApoB100) and glucose were examined in 67 patients with CHD and 107 healthy control subjects by biochemistry department;serum were extracted and put into speedVac system,and concentrated into 0.1 mL under 0℃,enzyme-linked immunosorbent assay(ELISA) method was used to determine ApoA5.ResultsCompared with control group,ApoA5 level of CHD groups was lower(P0.05),TC,TG and LDLC were higher(P0.01 or P0.05),the difference of HDLC,ApoA1 and ApoB100 were no significant(P0.05). In the groups of CHD patients with high TG and CHD patients with normal TG, the serum ApoA5 concentrations is obviously lower than that in healthy control group(P0.01),and in the group of CHD patients with high TG the serum ApoA5 concentrations is lower than that in the group of CHD patients with normal TG(P0.01). The level of ApoA5 was negatively correlated with plasma TG level(P0.01).The level of ApoA5 has positive tendency with the plasma HDL cholesterol,ApoA1,and glucose levels and negative tendency with TC,LDLC,ApoB100 levels, there were no significance(P0.05).ConclusionThe decrease of ApoA5 may be a risk fact.The level of ApoA5 was negatively correlated with plasma TG level.ApoA5 may be an important regulating factor in TG metabolism.