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2008•Journal of Shandong UniversityRequires access

Relationship between apolipoproteins A5 and lipids metabolism in elderly people

Lei Qiu

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Abstract

Objective To investigate the relationship between apolipoproteins A5 and lipids metabolism in elderly people.Methods The level of serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoproteinA1(APOA1),apolipoproteinB100(APOB100) and glucose were determined in 187 elderly people,and APOA5 in 1 mL serum was determined under-80 ℃ by the ELISA method.Results The APOA5 level was negatively correlated with plasma TG level(P0.01) and had a positive tendency with the plasma HDL cholesterol,APOA1 and glucose levels and a negative tendency with TC,LDL cholesterol and APOB100 levels,but the difference was not significant(P0.05).The APOA5 level was higher in mean than in women, but the difference was also not significant(P0.05).Conclusion The APOA5 level is negatively related to the plasma TG level.APOA5 may be an important regulatory mechanism in TG metabolism.

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Objective To investigate the relationship between apolipoproteins A5 and lipids metabolism in elderly people.Methods The level of serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoproteinA1(APOA1),apolipoproteinB100(APOB100) and glucose were determined in 187 elderly people,and APOA5 in 1 mL serum was determined under-80 ℃ by the ELISA method.Results The APOA5 level was negatively correlated with plasma TG level(P0.01) and had a positive tendency with the plasma HDL cholesterol,APOA1 and glucose levels and a negative tendency with TC,LDL cholesterol and APOB100 levels,but the difference was not significant(P0.05).The APOA5 level was higher in mean than in women, but the difference was also not significant(P0.05).Conclusion The APOA5 level is negatively related to the plasma TG level.APOA5 may be an important regulatory mechanism in TG metabolism.

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Available abstract

Objective To investigate the relationship between apolipoproteins A5 and lipids metabolism in elderly people.Methods The level of serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoproteinA1(APOA1),apolipoproteinB100(APOB100) and glucose were determined in 187 elderly people,and APOA5 in 1 mL serum was determined under-80 ℃ by the ELISA method.Results The APOA5 level was negatively correlated with plasma TG level(P0.01) and had a positive tendency with the plasma HDL cholesterol,APOA1 and glucose levels and a negative tendency with TC,LDL cholesterol and APOB100 levels,but the difference was not significant(P0.05).The APOA5 level was higher in mean than in women, but the difference was also not significant(P0.05).Conclusion The APOA5 level is negatively related to the plasma TG level.APOA5 may be an important regulatory mechanism in TG metabolism.

Key concepts: Triglyceride, Internal medicine, Endocrinology, Apolipoprotein B, Cholesterol, Metabolism, Lipid metabolism, Lipoprotein

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