Analysis of Blood Lipid Levels of the Patients with Coronary Heart Disease

Objective To evaluate the close correlation between blood lipids and coronary heart disease(CHD) and to provide predictive and diagnostic parameters for CHD. Methods Blood lipid levels of 180 patients with CHD and 40 healthy control subjects had been determined by immunonephelometry, enzyme assay and selective inhibition assay. Blood lipid parameters included low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1(ApoA1), apolipoprotein ApoB 100 (ApoB 100), total cholesterol (TC) and triglyceride (TG). Results Compared with control subjects, blood levels of TC, TG, ApoB100 and LDL-C in CHD group increased significantly. So did the ratios of LDL-C/HDL-C, LDL-C/ApoA1 and TC/HDL-C. Contrary, blood levels of HDL-C and ApoA1 and ApoA1/ApoB100 ratio significantly decreased (P0.01). There were abnormal Blood lipid parameters in 88.3% CHD patients showed by multiparameter combined analysis, which was far higher than the analysis of TC and TG alone (26.7%, P0.01). There were one or more abnormal blood lipid parameters in 84.1% non-hyperlipidemia patients with normal levels of TC and TG, which was higher than that in control subjects (P0.01). Frequency of abnormality in subjects with critical level of TC was higher than in subjects with expected level of TC (P0.05). Conclusion Abnormality of blood lipids was universal in CHD. There was close correlation between abnormal blood lipids and generation and development of CHD. Multiparameter combined analysis could evaluate the risk of CHD more accurately.