The clinical significance of measurement for PT,APTT and FIB in the patients with hepatitis B.

Objective To analyze the variation of the coagulation state and its clinical significance in the patients with hepatitis B.Methods 136 venous blood samples from the patients with hepatitis B were measured for plasm prothrombin time(PT),activated partial thromboplastic time(APTT),fibrinogen(FIB) by STA-Compact automated coagulation analyzer from the normal subjects were measured as control.Results The PT,APTT,FIB values of the groups of hepatocirrhosis and grievous hepatitis B showed clinically significant differences compared with the healthy control's.(P0.05,P0.01).However,the differences in PT,APTT values of the group of chronic hepatitis B were not significant(P0.05).FIB values of it showed significant differences compared with the healthy control's(P0.05).Conclusion The coagulation state in the patients with hepatitis B varied evidently during the deepen of the liver impairment.The abnormal values showed identical significance with the lever impairment.