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Relationship between hepatitis B virus basic core promoter/precore mutations and viral genotypes

Fang Ji-lian

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Abstract

Objective To investigate the relationship between hepatitis B virus(HBV) basic core promoter(BCP)/precore(PreC) mutations and viral genotypes. Methods Sera from 113 patients chronically infected with HBV were tested. HBV genotype was determined by S gene sequencing. Double mutation in BCP(T1762/A1764) and PreC mutation(A1896) were determined by INNO-LiPA. Results The double-mutation in BCP (T1762/A1764) was significantly more frequent in genotype C patients than that in B patients(34.2% vs 10.0%, χ 2=6.74,P0.01). However, there was no significant difference in the distribution of PreC mutant with A1896 between genotype B and C patients(2.5% vs 4.1%,χ 2=0.00,P0.05). Conclusion Compared with genotype B, the double-mutation in BCP(T1762/A1764) was more common in patients with genotype C patients.

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Objective To investigate the relationship between hepatitis B virus(HBV) basic core promoter(BCP)/precore(PreC) mutations and viral genotypes. Methods Sera from 113 patients chronically infected with HBV were tested. HBV genotype was determined by S gene sequencing. Double mutation in BCP(T1762/A1764) and PreC mutation(A1896) were determined by INNO-LiPA. Results The double-mutation in BCP (T1762/A1764) was significantly more frequent in genotype C patients than that in B patients(34.2% vs 10.0%, χ 2=6.74,P0.01). However, there was no significant difference in the distribution of PreC mutant with A1896 between genotype B and C patients(2.5% vs 4.1%,χ 2=0.00,P0.05). Conclusion Compared with genotype B, the double-mutation in BCP(T1762/A1764) was more common in patients with genotype C patients.

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Available abstract

Objective To investigate the relationship between hepatitis B virus(HBV) basic core promoter(BCP)/precore(PreC) mutations and viral genotypes. Methods Sera from 113 patients chronically infected with HBV were tested. HBV genotype was determined by S gene sequencing. Double mutation in BCP(T1762/A1764) and PreC mutation(A1896) were determined by INNO-LiPA. Results The double-mutation in BCP (T1762/A1764) was significantly more frequent in genotype C patients than that in B patients(34.2% vs 10.0%, χ 2=6.74,P0.01). However, there was no significant difference in the distribution of PreC mutant with A1896 between genotype B and C patients(2.5% vs 4.1%,χ 2=0.00,P0.05). Conclusion Compared with genotype B, the double-mutation in BCP(T1762/A1764) was more common in patients with genotype C patients.

Key concepts: Genotype, Virology, Hepatitis B virus, Mutation, Biology, Mutant, Virus, Gene

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