Morphological study on the anti hepatic fibrosis of tetrandrine in rats

OBJECTIVE To investigate the effects of tetrandrine on hepatic fibrosis in rats. METHODS The rats were randomly divided into some groups.Liver fibrosis was induced in rats by subcutaneous injection of 50% carbone tetrachloride oil solution for a period of 14 weeks. The treatment groups were treated with tetrandrine twice a week for 14 weeks. Histopathological examination was made in 4?th ,8?th,14?th week after experiment.A quantity of collagenous fibers were determined by using color image analysis system. RESULTS Hepatic steatosis gradually increased from 4?th week and decrease in 14?th week. Hepatic fibrosis gradually increase from 4th week and pseudo lobules are formed in 14th week. Hepatic steatosis and fibrosis in treatment groups are slighter than those in toxic group.A quantity of collagenous fibers in liver tissue are significantly lower in treatment groups than in toxic group. The effects of tetrandrine at 50?mg/kg dose are better than those at 30?mg/kg. CONCLUSION Tetrandrine has good effects in the treatment of hepatic steatosis and fibrosis induced by carbone tetrachloride oil in rats.