The application of pepsinogen I and pepsinogen II in screening for gastric cancer

Objective To explore the application of serum pepsinogen Ⅰ(PGⅠ),pepsinogen Ⅱ(PGⅡ)and corresponding PG ratio(PGR) in the screening of gastric cancer.Methods The concentration of PGⅠand PGⅡin 80 cases of gastric cancer,70 cases of atrophic gastritis,90 cases of gastric ulcer,80 cases of superficial gastritis and 100 healthy subjects were detected by latex enhanced immunoturbidimetric assay and calculating PGR.Results The concentration(ng/mL) of serum PGⅠin gastric cancer,atrophic gastritis,gastric ulcer,superficial gastritis and healthy control were(38.61±8.47),(43.16±8.88),(63.00±13.42),(48.10±4.62) and(56.21±7.60) respectively.The level of PGⅠin gastric cancer group and atrophic gastritis group were significantly lower than control group(P0.05).The concentration(ng/mL) of serum PGⅡwere(12.37±6.13),(13.01±5.17),(15.21±7.30),(8.02±4.03) and(10.89±3.81)respectively,there was no statistical difference among groups.The positive rates of PGⅠand PGⅡ in gastric cancer group and atrophic gastritis group were 92.50%,72.85% respectively,significantly higher than other groups(P0.05).Conclusion Detection of serum PGⅠand PGⅡ provides the evidence for screening and diagnosis of early gastric cancer and atrophic gastritis.