Clinical Observation of Efficacy and Safety of Mifepristone Combined with Misoprostol in the Treatment of Missed Abortion

Objective To investigate the efficacy and safety of mifepristone combined with misoprostol in the treatment of missed abortion. Methods 68 patients of missed abortion were taken as the observation group and given 50mg of mifepristone in the morning and evening respectively for two days. On the third day,they were given 0. 6 mg of misoprostol orally and then received complete curettage of uterine cavity after the gestation tissue was drained naturally. 70 missed abortion patients were taken as the control group,which were treated with 5mg diethylstilbestrol,three times daily for three days. Oxytocin was injected into the vein,and complete curettage of uterine cavity was carried out after the gestation tissue was drained naturally. The two groups of the patients were compared and observed after the operation. Results The natural drain rate of the tissue inside the uterine cavity of the observation group is obviously higher than that of the control group( P 0. 01). The adverse effects rate,syndrome of induced abortion operation and the amount of bleeding are all lower than that of the control group( P 0. 01). Conclusion The mifepristone combined with misoprostol in the treatment of missed abortion is safe and effective,and this therapy is worth promoting.