2004•Chinese New Drugs JournalRequires access
Protective effects of gefarnate on gastric mucosal lesions induced by aspirin in rats
Guibin Yang
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Abstract
Objective:To determine the protective effects of gefarnate on gastric mucosal lesions induced by aspirin in rats. Methods:60 healthy male Wistar rats were randomly and equally divided in-to six groups:normal group,injury group,gefarnate protective group(400mg·kg-1) ,bismuth potassi-um citrate protective group (80mg·kg-1), misoprostol protective group(0.1mg·kg-1) and sucralfate protective group(0. 5g·kg-1). Gastric mucosal lesions were induced by intraperitoneal administration of aspirin. Rats of protective groups were pretreated with drugs that mentioned above respectively be-fore induction of gastric mucosal lesions. Gastric mucosal blood flow and content of hexosamine were measured and the histological changes were evaluated under microscope. Results: Compared with injury group,ulcer index of protective groups were significantly decreased(P0.001),gastric mucosal blood flow and content of hexosamine were significantly increased(P0. 001). Inflammation and injury in histological slide of protective groups were slight. Conclusion: Gefarnate can reduce gastric mucosal lesions induced by aspirin in rats,its protective effect is similar to those of bismuth potassium citrate and misoprostol and superior to that of sucralfate.