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Protective Effects of Gefarnate on Gastric Mucosal Lesions Induced by DMF and Alcohol in Rats

Zheng Xue-fen

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Abstract

To determine the protective effects of gefarnate on gastric mucosal lesions induced by Dimethylformamide(DMF) and alcohol in rats,30 healthy male Wistar rats were randomly and equally divided into four groups: normal group,injury group,gefarnate protective group(400mg/kg).Gastric mucosal lesions were induced by DMF and alcohol.Rats of protective groups were pretreated with drugs that mentioned above respectively before induction of gastric mucosal lesions.Gastric mucosal blood flow and content of hexosamine were measured and the histological changes were evaluated under microscope.Compared with injury group,ulcer index of protective groups were significantly decreased(P0.001),gastric mucosal blood flow and content of hexosamine were significantly increased(P0.001).Inflammation and injury in histological slide of protective groups were slight.Gefarnate can reduce gastric mucosal lesions induced by DMF and alcohol in rats.

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What this paper is about

To determine the protective effects of gefarnate on gastric mucosal lesions induced by Dimethylformamide(DMF) and alcohol in rats,30 healthy male Wistar rats were randomly and equally divided into four groups: normal group,injury group,gefarnate protective group(400mg/kg).Gastric mucosal lesions were induced by DMF and alcohol.Rats of protective groups were pretreated with drugs that mentioned above respectively before induction of gastric mucosal lesions.Gastric mucosal blood flow and content of hexosamine were measured and the histological changes were evaluated under microscope.Compared with injury group,ulcer index of protective groups were significantly decreased(P0.001),gastric mucosal blood flow and content of hexosamine were significantly increased(P0.001).Inflammation and injury in histological slide of protective groups were slight.Gefarnate can reduce gastric mucosal lesions induced by DMF and alcohol in rats.

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Available abstract

To determine the protective effects of gefarnate on gastric mucosal lesions induced by Dimethylformamide(DMF) and alcohol in rats,30 healthy male Wistar rats were randomly and equally divided into four groups: normal group,injury group,gefarnate protective group(400mg/kg).Gastric mucosal lesions were induced by DMF and alcohol.Rats of protective groups were pretreated with drugs that mentioned above respectively before induction of gastric mucosal lesions.Gastric mucosal blood flow and content of hexosamine were measured and the histological changes were evaluated under microscope.Compared with injury group,ulcer index of protective groups were significantly decreased(P0.001),gastric mucosal blood flow and content of hexosamine were significantly increased(P0.001).Inflammation and injury in histological slide of protective groups were slight.Gefarnate can reduce gastric mucosal lesions induced by DMF and alcohol in rats.

Key concepts: Mucosal lesions, Ulcer index, Alcohol, Medicine, Internal medicine, Gastroenterology, Gastric mucosa, Inflammation

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Protective Effects of Gefarnate on Gastric Mucosal Lesions Induced by DMF and Alcohol in Rats — Research Paper | ScholarLens