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2008•Strait Pharmaceutical JournalRequires access

Determination of Danshensu in Guanmaining capsules by HPLC

Lin Xue-ying

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Abstract

OBJECTIVE To establish an HPLC method for the determination of Danshensu in Guanmaining capsules.METHODS Phenomenex C18 column(4.6mm ×250 mm,5μm) was used and the mobile phase consisted of methanol-water-glacial acetic acid(10∶90∶1) with the flow rate of 1.0mL·min-1,the UV-detection wavelength was 280nm.RESULTS The linear range of Danshensu was 0.03468～0.6936mg(r=0.9995),the recovery rate was 99.7%,and RSD was 1.16%.CONCLUSION The method is simple,accurate and stable.

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What this paper is about

OBJECTIVE To establish an HPLC method for the determination of Danshensu in Guanmaining capsules.METHODS Phenomenex C18 column(4.6mm ×250 mm,5μm) was used and the mobile phase consisted of methanol-water-glacial acetic acid(10∶90∶1) with the flow rate of 1.0mL·min-1,the UV-detection wavelength was 280nm.RESULTS The linear range of Danshensu was 0.03468～0.6936mg(r=0.9995),the recovery rate was 99.7%,and RSD was 1.16%.CONCLUSION The method is simple,accurate and stable.

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Available abstract

OBJECTIVE To establish an HPLC method for the determination of Danshensu in Guanmaining capsules.METHODS Phenomenex C18 column(4.6mm ×250 mm,5μm) was used and the mobile phase consisted of methanol-water-glacial acetic acid(10∶90∶1) with the flow rate of 1.0mL·min-1,the UV-detection wavelength was 280nm.RESULTS The linear range of Danshensu was 0.03468～0.6936mg(r=0.9995),the recovery rate was 99.7%,and RSD was 1.16%.CONCLUSION The method is simple,accurate and stable.

Key concepts: Chromatography, Chemistry, High-performance liquid chromatography, Acetic acid, Methanol, Linear relationship, Mathematics, Biochemistry

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