Clinical value of serum retinol binding protein 4 in early diagnosis of diabetic nephropathy

Objective To discuss the clinical value of retinol binding protein 4(RBP4) in the diagnosis of early impairment of renal.Methods According to urinary albumin excretion rate in 232 patients with diabetes were divided into early DN group,clinical stage DN group,treatment period of DN group,simple DN group,and 60 healthy subjects,who were detected by serum RBP4,Cys-C,BUN,Cr and statistical analysis(t test and χ2 test).Results RBP4 level in the early DN group was significantly higher than the simple DN group,the difference was statistically significant(t=6.704 3,P0.01),showing the positive correlation with the result of Cys-C test at the same period.There was no significant difference in the results of BUN and Cr tests between the early DN group and simple DN group(P0.05).The sensitivity of RBP4 in early DN group was higher than that of Cys-C,BUN and Cr.The positive rate of RBP4 in early DN group(62.1%) was significantly higher than the one in treatment period of DN group(27.6%)(χ2=13.942 3,P0.01).Conclusion The serum RBP4 is a good biomarker to inspect the early impairment of renal,which can be treated as the index for the regular screening and monitoring of early diagnosis and judgment of curative effect of diabetic nephropathy.