The early diagnostic value of serum Cys-C、β_2-MG、RBP in patients with diabetic nephropathy

Objective To evaluate the Cys-C、β_2-MG,RBP as marker三of early diagnosis in patients with diabetic nephropathyⅡ(DN).Methods ninety patients with DN were divided into three groups according to urinary albumin excretion rate (UAER),that is normal,micro and mass group.Serum Cys-C、β_2-MG、RBP、BUN、Crea were detected and parallelly contrasted in the three groups and control group with thirty healthy people.Results compared with the control group,the serum Cys-C、β_2-MG、RBP of micro and mass group both significantly increased and the normal group had no significant difference.The positive rate of Cys-C、β_2-MG、RBP in mass group was respectively 100%、100%、96.l%;the positive rate in micro group as follows:Cys C (92.3%)B2-MG(84.6%)RBP(66.6%)Crea(46.1%)BUN(28.2%).Conclusion serum Cys-C、β_2-MG、RBP have high positive rates in patients with diabetic nephropathyⅡ(DN).They can be used as early diagnostic marker of diabetic nephropathyⅡespecially Cys-C.