Relationship between the level of serum carcinoembryonic antigen and carbohydrate antigen in staging,metastasis and prognosis of lung cancer

Objective:To study the value of serum carcinoembryonic antigen(CEA) and carbohydrate antigens(CA15-3,CA19-9 and CA125) in staging,metastasis and prognosis of patients with lung cancer.Methods:The level of CEA,CA15-3,CA19-9 and CA125 were measured in 30 lung cancer,30 lung benign disease and 30 healthy controls with IMMULITE enzyme amplification chemiluminescence immunoassay system.All patients were followed up for 2 years.Results:The level of CEA,CA15-3 and CA125 in patients with lung cancer was significantly higher than that of pulmonary benign diseases(P0.05) and healthy controls(P 0.01).The level of CA19-9 in patients with lung cancer was significantly higher than that of pulmonary benign diseases(P0.01),but had no significant difference when it was compared with pulmonary benign diseases.There had no significant difference in CEA,CA15-3,CA19-9 and CA125 in different stages of lung caner.The possibility of metastasis and recurrence was significantly higher for lung cancer patients with positive CEA and CA125 than those with negative CEA and CA125(P0.01).During the follow-up period,there were 14 patients died of recurrence or metastasis.The prognosis of patients with positive CEA was worse than those with negative CEA,and there was significant difference in survival rate(P0.05).Conclusion:The serum CEA and carbohydrate antigens CA125 are valuable in metastasis and prognosis of patients with lung cancer.